Två kliniska studier har gjorts: Den en studien undersökte 10 personer, som ökade sitt maximala ut- och inandningstryck med i snitt 11 procent efter att ha tränat med WellO2 i tre veckor. Den andra undersökte 12 personer med röstrubbningar relaterade till andningsproblem. Röstrubbningarna minskade efter träning med WellO2.
Det finns också ett flertal undersökningar som separat forskat i motståndsandningens och ångandningens effekter vid olika typer av andningssvårigheter. Nedan följer en förteckning över ett antal referenser:
1. Tyrrell D., et al. Local hyperthermia benefits natural and experimental common colds. 1989, BMJ. 298:1280-3
2. Conti C., et al. Antiviral effect of hyperthermic treatment in rhinovirus infection. Antimicrob Agents Chemother, 1999;43(4):822-9
3. Sebastian L., et al. The effect of local hyperthermia on allergen-induced nasal congestion and mediator release. J Allergy Clin Immunol 1993, 92:850-6.
4. Desrosiers M. et al. Treatment with hot, humid air reduces the nasal response to allergen challenge. J Allergy Clin Immunol 1997, 99:77-86.
5. Foxman et al. Two interferon-independent double-stranded RNA induced host defence strategies suppress the common cold virus at warm temperature. PNAS, July 26, 2016, vol. 113, no. 30.
6. Foxman et al. Temperature-dependent innate defence against the common cold virus limits viral replication at warm temperature in mouse airway cells. PNAS, 2015, vol 112, no. 3.
7. Jing J.C. et al. Scientific REPORTS | 7: 8522 | DOI:10.1038/s41598-017-08968-x. Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography 2017.
8. Vora S.U. et. al. Effect of Steam Inhalation on Mucociliary Activity in Patients of Chronic Pulmonary Disease. Indian J Chest Dis Allied Sci, 1993, 35 (1), 31-4 Jan-Mar .
9. Pick HJ., et al. P25 Inspiratory muscle training (IMT) for adults discharged from hospital with community acquired pneumonia (CAP) – a feasibility study. Thorax, 2018, Vol. 73, Issue Suppl 4.
10. Björkqvist M., et al. Bottle-blowing in Hospital-treated Patients with Community-acquired Pneumonia. J Scand Inf. Dis. 1997, 29/1.